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Acquired Von Willebrand Syndrome in Chronic Myelogenous Leukemia Presenting with Severe Thrombocytosis

Case Report, Volume 12 Issue 2 – April to June 2019

Authors

Deepak Chandraa, Deepa Jayakrishnanb, Bijay Nairc
aDepartment of Internal Medicine, University of Arkansas for Medical Sciences, Arkansas, USA;
bHarmony Clinic, Arkansas, USA; Little Rock Hematology/Oncology, CARTI, Arkansas, USA;
cLittle Rock Hematology/Oncology, CARTI, Arkansas, USA


Abstract

Background: Acquired von Willebrand syndrome (AVWS) is a bleeding disorder caused by acquired abnormalities in von Willebrand factor. It occurs in association with several malignant diseases as well as cardiovascular conditions.
Case Presentation: We present here the case of a woman without any family history of bleeding disorders, who presented with recurrent epistaxis from AVWS in the context of very high platelet count secondary to chronic myelogenous leukemia (CML).
Conclusion: Her bleeding resolved with treatment of her underlying CML.
Keywords: Acquired von Willebrand syndrome, Chronic Myelogenous Leukemia, Thrombocytosis


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