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RT-PCR Negative COVID 19 – Akin to Smear Negative Pulmonary Tuberculosis? – A Case Report

Case Report, Volume 14 Issue 1 – January to March 2021

Authors

Ganesh Ba, Arjun Pa, Ameer KAa, Vinodkumar Kesavana, Rajalakshmi Ab, Muhammad Niyasb, Muralidharan Rc, Deepak Vc
aDepartment of Respiratory Medicine, Kerala Institute of Medical Sciences, Trivandrum;
bDepartment of Infectious Diseases, Kerala Institute of Medical Sciences, Anayara P.O, Trivandrum;
cDepartment of Critical Care Medicine, Kerala Institute of Medical Sciences, Anayara P.O, Trivandrum


Abstract

We report a case of 34-year-old physician who presented with classical clinicoradiological features suggestive of COVID-19 but five sequential rRT-PCR (real time Reverse Transcription Polymerase chain reaction) tests were negative. After admission, he was hypoxic and febrile. He had clinical worsening and laboratory parameters suggestive of an impending cytokine storm and he was appropriately managed as per institution protocol. Meanwhile, his antibody test for COVID 19 came positive for both Ig G and Ig M with high IgM level. He had a dramatic recovery and was discharged within 10 days. It is difficult to distinguish COVID-19 pneumonia from other viral pneumonia based on RT-PCR and CT findings alone. In this context, this case report is being published to highlight this fact.


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