Authors
Iype Marya, Radhakrishnan Neelimab, Ahamed M Shahanazb, Radhakrishnan NSb, Sankar VHc, Radhakrishnan VVc
aDepartment of Paediatric Neurology, Government Medical College. Trivandrum;
bDepartment of Pathology, Sree Chitra Thirunal Institute of Medical Sciences & Technology;
cDepartment of Paediatrics, Government Medical College, Trivandrum
Abstract
Introduction: Myositis is the inflammation of voluntary muscles, characterized by pain, tenderness, swelling, and/or weakness, with causes including infection and autoimmune conditions.
Case Presentation: We present two male children from South India who, three weeks apart, developed persistent myositis and subacute myoglobinuria. Their near-simultaneous presentation and non-specific vacuolar changes on muscle histopathology suggested an infective etiology.
Results: Both cases achieved complete recovery with Intravenous Immunoglobulin (IVIg), without residual disease or renal involvement, despite significant myoglobinuria.
Conclusion: These cases are notable as published literature lacks reports of non-immune myositis resolving completely with IVIg. This report highlights that myositis can be non-self-limiting and disabling, necessitating specific treatment.